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For use in large & giant breed dogs. Recommended to support healthy teeth, gums and breath odor. The ProDen PlaqueOff® key ingredient is 100% natural kelp and is sustainably harvested in the clear, cold waters off the Scandinavian coastline. Clinical trials on our kelp have shown to help reduce plaque and tartar while helping to improve bad breath. Veterinarian Formulated & Recommended. Easy to use Results within 2-3 weeks